The biggest fire in the U.S. took place Oct. 8, 1872 in Peshtigo, Wis. The blaze burned 16 towns, killed 1,152 people, and burned 1.2 million acres, according to the National Fire Protection Agency. Historical accounts of the fire say that it began when railroad workers unintentionally started a brush fire and within an hour there was nothing left of the town but ashes.
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